- Student Government Association
- African American Association
- Art Club
- Basketball Club
- College Democrats
- American Dental Hygienists
- College Republicans
- Communications Club
- Dental Students Association
- DeSoto Campus Ambassadors
- Hardee Campus Ambassadors
- Hispanic Students Organization
- Jac Pac
- Phi Theta Kappa
- Radiography Club
- Rotaract
- Student Nurses Association
- Student Practical Nurses
College Republicans
College Republicans is a political interest club that is active in the politics of the area, the state, and the nation.
