- College Week
- Student Government Association
- African American Association
- American Dental Hygienists
- Anime Gaming Club
- Art Club
- College Republicans
- Collegiate FFA
- Communications Club
- Auto Collision Club
- Basketball Club
- Campus Christian Club
- Circle K of South Florida State College
- College Democrats
- Dental Students Association
- DeSoto Campus Ambassadors
- EMS Student Association
- Hardee Campus Ambassadors
- Health Occupations Students of America
- Hispanic Students Organization
- Honors Ambassadors
- Jac Pac
- Performing Arts Club
- Phi Beta Lambda
- Phi Theta Kappa
- Radiography Club
- Rotaract
- Soccer Club
- Student Nurses Association
- Student Practical Nurses
College Republicans
College Republicans is a political interest club that is active in the politics of the area, the state, and the nation.
